• How Natural Killer Cells Recognize Self
• 53 min
  1. Education and tuning of natural killer cells

  • Prof. Eric Vivier
  • Dr. Sophie Ugolini
• 46 min
  2. Disarming of autoreactive NK cells

  • Prof. David Raulet
• Development and Function of Natural Killer Cell Subsets
• 23 min
  3. Natural killer cell development

  • Dr. Francesco Colucci
• 48 min
  4. Natural killer cells: development, diversity and applications to human disease

  • Prof. Mike Caligiuri
• 41 min
  5. NK cells in viral immunity

  • Prof. Lewis Lanier
• 58 min
  6. NK cell subsets and interactions with dendritic cells

  • Prof. Christian Münz
• 53 min
  7. Immunodeficiencies and genetic mutations affecting NK cells in humans

  • Dr. Jordan Orange
• Natural Killer Cell Receptors and Signaling
• 42 min
  8. Evolution of NK cell receptors

  • Prof. John Trowsdale
• 26 min
  9. The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease

  • Dr. Mary Carrington
• 37 min
  10. Mechanisms of natural killer cell cytotoxicity

  • Prof. Carsten Watzl
• 55 min
  11. NK cell signaling to cytotoxicity - part I

  • Prof. Dan Billadeau
• 39 min
  12. NK cell signaling to cytotoxicity - parts II & III

  • Prof. Dan Billadeau
• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  13. NK cells in viral immunity

  • Prof. Lewis Lanier

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Part II: the NKG2D-DAP10 signaling complex
3. The human NKG2D-DAP10 complex
4. Importance of YINM motif in DAP10 signaling
5. Coupling to p85 and Grb2/Vav
6. Grb2: signaling and activation
7. PI3K is required for NKG2D-mediated killing
8. CrkL regulates conjugate formation
9. Rap1 activation by NKG2D
10. JNK1 activation by NKG2D
11. Summary of part II
12. Part III: inhibitory receptor signaling
13. iKIR crosslinking leads SHP1 recruitment
14. SHP1 binds directly to the ITIM motif
15. iKIR engagement blocks signaling
16. Catalytically-inactive SHP1 leads to cell death
17. What are the targets of SHP1?
18. Vav1 is a target of SHP1
19. Summary of part III
20. Acknowledgements

Topics Covered

• Regulation of killing by the NKG2D/DAP10 receptor complex
• PI3K pathway regulates cell adhesion and MTOC polarization through a CrkL-Rap1 activation
• Grb2/Vav1 pathway regulates SLP-76 and PLCγ2 activation, calcium signaling and cell-mediated killing
• Inhibitory signaling from killer immunoglobulin receptors that recruit the tyrosine phosphatase SHP1
• SHP1 targets

Links

Series:

• Natural Killer Cell Biology

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 20, 2010

Financial Disclosures

• Prof. Dan Billadeau has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.