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- RNAi-Pathway Components and Mechanisms
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1. Activation of gene expression by double-stranded RNAs
- Prof. Long-Cheng Li
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2. MicroRNA biogenesis
- Dr. Narry Kim
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3. Dicer and R2D2
- Dr. Young Sik Lee
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4. Mammalian microRNA assembly and function
- Prof. Zissimos Mourelatos
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5. Mechanisms of RNAi: a molecular view or Argonaute: the secret life of Slicer
- Prof. Leemor Joshua-Tor
- Roles for RNAi in Development and Anti-Viral Defense
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6. Functional roles of RNAi in C. elegans
- Dr. Eric Miska
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7. RNAi and heterochromatin in plants and fission yeast
- Prof. Robert Martienssen
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8. RNA interference functions and mechanisms in animals
- Prof. Richard Carthew
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9. Specific functional roles in mammals
- Dr. Michael McManus
- RNAi Design Rules for Applications in Humans
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10. siRNA on and off-target
- Prof. Anastasia Khvorova
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11. Cell signalling pathways and RNAi
- Mr. Michael O'Grady
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12. RNAi: key technological aspects
- Dr. Dmitry Samarsky
- Dr. Ciaran Faherty
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13. RNAi specificity: how big of an issue is it?
- Dr. Peter Welch
- Applications of RNAi in the Treatment of Human Diseases
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14. siRNA therapeutics
- Prof. John Rossi
- Mr. Daniel J. Rossi
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15. RNAi for neurological diseases
- Prof. Beverly L. Davidson
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16. RNA interference and cancer: a revolution?
- Dr. Annick Harel-Bellan
- Archived Lectures *These may not cover the latest advances in the field
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17. RNAi and viral heart infections
- Dr. Jens Kurreck
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18. RNA interference for neurodegenerative diseases
- Prof. Beverly L. Davidson
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19. Activation of gene expression by double-stranded RNA
- Prof. David Corey
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20. New designs for siRNAs as Dicer substrate
- Dr. Mark Behlke
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21. RNAi in the model system Drosophila
- Prof. Richard Carthew
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23. Therapeutic delivery of RNAi
- Dr. Patrick Lu
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24. Mechanistic aspects and therapeutic applications of RNAi
- Prof. John Rossi
Printable Handouts
Navigable Slide Index
- Introduction
- Overview - a brief history
- Short RNAs are key players of gene regulation
- Overview - the phenomenon of RNAi
- The discovery of RNAi in C.elegans
- RNAi in C.elegans is systemic
- RNAi in other organisms
- Delivery of RNAi (dsRNA)
- Overview - a genetic pathway for RNAi
- A genetic screen for RNAi pathway identification
- Genes required for RNAi
- RNAi, transposon silencing and co-suppression
- RNAi, transposon silencing, co-suppression genes
- Identification of new RNAi genes
- Identification of new RNAi genes - biochemistry
- Systemic RNAi: the genetics of spreading
- RNAi spreading - C.elegans experiments
- Genes of RNAi spreading
- Overview - RNAs and endogenous RNAi
- A short history of microRNAs
- Biogenesis of microRNAs
- Links between microRNA biogenesis and RNAi
- Clustering of mIR-35 family genes
- MicroRNA families in C. elegans
- The conserved let-7 family
- Cell divisions in C.elegans development
- lin-4(lf) mutants change cell divisions of the L1
- Heterochronic phenotypes: precocious or retarded
- MicroRNAs that control developmental switches
- let-7 family members control developmental timing
- Control of early and late developmental switch
- Emerging roles for microRNA
- Other small RNAs
- Overview - RNAi screening
- Whole genome RNAi screens - methods
- Whole genome screens: advantages and problems
- Whole genome screens: abnormal phenotypes
- Overview - biology of RNAi in C. elegans
- Biological roles for RNAi
- RNAi as the guardian of the genome
- References (1)
- References (2)
Topics Covered
- Small non-coding RNA pathways
- Genetics of RNAi
- MicroRNAs
- RNAi screening
- Biological roles of RNAi
- Systemic RNAi in C. elegans
Talk Citation
Miska, E. (2020, September 10). Functional roles of RNAi in C. elegans [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 19, 2024, from https://hstalks.com/bs/644/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Eric Miska has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.