• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 51 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Follow up of a previous lecture
3. Messages
4. Overview
5. What is exocytosis?
6. Eukaryotes
7. Inventions
8. Endolysosome
9. Lysosome
10. Development of metazoans
11. Quantal theory of neurotransmitter release
12. Regulated exocytosis in astrocytes
13. Electrophysiology & photolysis of caged calcium (1)
14. Electrophysiology & photolysis of caged calcium (2)
15. Electrophysiology & photolysis of caged calcium (3)
16. Changing calcium in astrocytes
17. Ca2+ dependence of the rate of exocytosis in various secretory cells
18. Ca2+-dependent exocytosis in astrocytes (1)
19. Regulated exocytosis requires the SNARE proteins
20. Ca2+-dependent exocytosis in astrocytes (2)
21. Microscopy studies
22. Gliocrine astrocytes release a myriad of gliosignals via vesicles
23. Vesicles and exocytosis
24. Monitoring single vesicle fusion (discrete changes in Cm)
25. Single-vesicle studies in astrocytes
26. Two vesicle size populations in astrocytes
27. Fusion pore conductance depends on vesicle diameter
28. Vesicle cholesterol
29. SNARE complex and vesicle cholesterol affect the transitions from reversible to full fusion
30. SNAP-23 replaces SNAP-25 in astrocytes
31. Ca2+-dependent exocytosis in astrocytes (3)
32. Vesicle mobility
33. Directional and non-directional mobility
34. Directional mobility requires cytoskeletal elements
35. Peptidergic vesicles
36. Anti-VGLUT1 vesicle mobility in astrocytes
37. Purinergic vesicles
38. Reactive astrocytes
39. Vesicle mobility & cytoskeletal filaments
40. IFs and vesicle mobility
41. Reactive astrogliosis in vitro
42. Endolysosomal vesicle mobility
43. Vesicle membrane interactions
44. Summary
45. Antigen presentation
46. Reactive astrocytes in vitro
47. IFNγ and reversible fusion of vesicles
48. Mobility of MHC-II vesicles and intermediate filaments
49. Conclusions
50. Acknowledgements

Topics Covered

• Exocytosis
• Calcium-dependent exocytosis in astrocytes
• SNARE proteins
• Gliocrine astrocytes
• Vesicle fusion
• Vesicle cholesterol
• Vesicle mobility
• Peptidergic vesicles
• Purinergic vesicles
• Reactive astrocytes
• Reactive astrogliosis in vitro
• Vesicle membrane interactions

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Cell Biology
• Neuroscience
• Physiology & Anatomy

Therapeutic Areas:

• Neurology

External Links

• “Properties of Regulated Exocytosis in Astrocytes”, HSTalks 2014

Talk Citation

Zorec, R. (2023, September 28). Exocytosis and gliocrine astroglia [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 18, 2024, from https://hstalks.com/bs/5413/.
Export Citation (RIS)

Publication History

• Published on September 28, 2023

Financial Disclosures

• There are no commercial/financial disclosures.