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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Review
- Apoptosis signaling pathways
- Responses triggered by TNF-family receptors
- TNF-SF structure-function: TNF ligands
- TNF receptors: extracellular domains
- TNF ligand: receptor binding
- Death domain
- Apoptosis triggered through recruitment of DISC
- Regulation of early death receptor signaling (1)
- Preassociation of fas and other TNFRs
- TNF-SF receptors without death domain
- Spectrum of receptors in the TNF-R superfamily
- TNF receptor dual signaling : the 2 complex model
- Alternative caspase-independent cell death
- Elimination of restimulted T cells is clonotypic
- TCR stimulation sensitizes cells to die via fas
- Lipid rafts in antigen receptor signal transduction
- TCR restimulation results in relocalization of fas
- Relocalization increases sensitivity to apoptosis
- Fas vs. TNFR1
- Regulation of early death receptor signaling (2)
- Fas engagement induces rapid receptor clustering
- Formation of SPOTS is dependent on Fas / FADD
- Two phases of Fas receptor redistribution
- SPOTS localization and enhancement
- SPOTS: platforms for Fas signaling
- The Fas pathway
- The death receptor signaling pathway
- Death receptors in T cells homeostasis
- Fas (TNFRSF 6): negative regulation
- TNF: inflammation and enhancement of immunity
- DR3: a T cell costimulator?
- TRAIL: cancer and innate immunity
- Other TNF family recepotrs with a death domain
- ALPS: genetic defects in the Fas pathway
- Two ALPS mutation interference mechanisms
- Relationship between Fas mutations and disease
- TRAP syndrome
- TRAPS-associated TNFR1 mutations
- Sources for further reading
Topics Covered
- Death Receptors and ligands
- Structural features
- receptor signalling complexes
- Regulation of death receptor signalling
- Receptor oligomerization and internalization
- Genetic diseases affecting death receptors
- Manipulating death receptors with therapeutics
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Siegel, R. (2007, October 1). The death receptor signalling pathway [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 2, 2024, from https://hstalks.com/bs/279/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Richard Siegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.