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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture topics
- Stem cell - definition
- Stem cell - asymmetric and symmetric division
- Stem cell - clonogenicity
- Stem cells - embryonic or adult
- What's an embryonic stem cell
- ES cells - derivation of genetically modified mice
- ES cells develop normally after reintroduction
- What's an adult stem cell
- The difference between adult stem cells and ES
- Extrinsic and intrinsic renewal factors - mouse ES
- Extrinsic and intrinsic renewal factors - human ES
- What's immortality
- The bus theory
- Stem cells are potentially immortal and dangerous
- Why is immortality dangerous
- Why does an immortal organism die
- Non-immortal organism
- Normal cells have a restricted capacity to divide
- How is programmed cell death advantageous
- First strategy for generating an organism
- Second strategy for generating an organism
- The difference between the two strategies
- Being mortal protects from cancer
- Other causes for cellular death
- Apoptosis
- Apoptosis - extrinsic and intrinsic pathways
- Telomere shortening (1)
- Telomeres are the ends of chromosomes
- Telomeres - T loops
- DNA replication
- Telomere shortening (2)
- Stem cells overcome telomere shortening
- TERT expression reverses senescence
- The impact of regenerative medicine
- Regenerative medicine - perspectives
- Ways that regenerative medicine can affect us
- Adult stem cells in clinical trials
- Regenerative medicine can raise the lifespan
- Hurdles of ES-derived regenerative medicine
- Efficacy of regenerative medicine - studies
- Immune rejection
- Safety - tumorigenicity
- Safety - teratomas
- Additional safety provided by cell engineering
- Regulatory acceptance
- Conclusion
Topics Covered
- What is a stem cell?
- Properties of stem cells
- Adult and embryonic stem cells
- What is immortality?
- Why do we die?
- Mechanisms of programmed cell death
- Mutation
- Connection between tumour protection and ageing
- Impact of regenerative medicine
- Impact of stem cells on lifespan
- Average and maximum lifespan
Talk Citation
McWhir, J. (2009, August 25). Stem cells: immortality or a healthy old age? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 8, 2024, from https://hstalks.com/bs/236/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jim McWhir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.