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- Evolutionary Perspectives
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1. Antibiotic resistance: a mechanistic overview
- Dr. Neil Woodford
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2. Mutation
- Prof. Stephen Gillespie
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3. Fitness in antibiotic resistant bacteria
- Prof. Stephen Gillespie
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4. Fitness and compensation
- Dr. Sébastian Gagneux
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5. Antibiotic resistance and the supragenome hypothesis
- Dr. Bambos Charalambous
- Epidemiology and Clinical Impact
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6. Methicillin resistant S. aureus and other resistances
- Prof. Mark Enright
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7. Risk factors for antibiotic resistance in Streptococcus pneumoniae
- Prof. Keith Klugman
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8. Beta-lactamases: clinical impact and epidemiology
- Prof. Sebastian Amyes
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9. Glycopeptide-resistant enterococci
- Dr. Neil Woodford
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10. Drug resistant tuberculosis: biology, epidemiology and control
- Dr. Christopher Dye
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11. Antiretroviral drug resistance
- Prof. Deenan Pillay
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12. Malaria - changing paradigms
- Dr. Janet Cox-Singh
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13. Advances in mode of action of antimalarials and resistance mechanisms 1
- Prof. David Warhurst
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14. Advances in mode of action of antimalarials and resistance mechanisms 2
- Prof. David Warhurst
- Diagnosis and Surveillance of Resistance
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15. Conventional and automated diagnostic methods
- Dr. Alan Johnson
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16. National and international surveillance of antibiotic resistance 1
- Prof. David Livermore
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17. National and international surveillance of antibiotic resistance 2
- Prof. David Livermore
- Controlling Antibiotic Resistance
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18. Controlling antibiotic resistance in the hospital environment
- Dr. Ian Eltringham
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19. Controlling antibiotic resistance in the community
- Dr. Peter Wilson
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20. Public policy to reduce antibiotic resistance
- Dr. Niels Frimodt-Møller
- The Antibiotic Resistance Future
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21. Overcoming resistance through novel drug targets
- Prof. Anthony Coates
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22. Medicinal chemistry strategies in combating antibiotic resistance
- Dr. Geoffrey Coxon
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23. Teixobactin kills pathogens without detectable resistance
- Prof. Kim Lewis
- Archived Lectures *These may not cover the latest advances in the field
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24. Molecular diagnosis of antibiotic resistance
- Dr. Tim McHugh
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25. Introduction to malaria
- Prof. David Warhurst
Printable Handouts
Navigable Slide Index
- Introduction
- Mechanisms of antibiotic action
- Resistance is as old as antibiotics
- Antibiotic resistance mechanisms
- Types of resistance
- Defining resistance
- Susceptibility is an interplay of multiple factors
- Antibiotics select resistant bacteria
- Bacteria carry resistance in their DNA
- Resistance is transferred (1)
- Resistance is transferred (2)
- The Red Queen Principle
- Resistance is inevitable
- How quickly does resistance emerge?
- Oxazolidinone timeline
- Mechanism 1: alteration of the target
- The forensics of antibiotic resistance
- Epidemiological investigation of resistance
- Surveillance of resistance
- An example of a trend noticed in surveillance
- Mechanism 2: metabolic by-pass
- Cephalosporin-resistant E. coli
- Why might resistance rates rise?
- Understanding rising prevalence
- Mechanism 3: drug destruction
- Global explosion of CTX-M ESBLs
- Multi-resistance plasmids
- The use of carbapenems
- Mechanism 4: reduced uptake
- Restore porins and reverse carbapenem resistance
- Carbapenemase-mediated resistance in the UK
- The OXA-23 clone 1
- Mechanism 5: up-regulated efflux
- Recap: mechanisms of resistance
- Undefined mechanism of action
- Undefined resistance mechanisms
- Summary
- Acknowledgements
Topics Covered
- Modes of antibiotic action
- Modes of resistance
- Intrinsic / acquired resistance
- Emergence and transfer of resistance
- Monitoring spread
- Modified targets
- Enzymic destruction
- ESBLs
- Plasmidic multi-resistance
- Impermeability / porin loss
- Carbapenemases
- Efflux pumps
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Woodford, N. (2009, December 31). Antibiotic resistance: a mechanistic overview [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 4, 2024, from https://hstalks.com/bs/1530/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Neil Woodford has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.