Henry Stewart Talks

The Biomedical & Life Sciences Collection

Online Seminars By Leading World Experts

Welcome to The Biomedical & Life Sciences Collection

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This collection of specially prepared animated audio visual presentations with synchronized narration is regularly updated and growing with over 1,500 talks.


Play 'Presynaptic plasticity'
Presynaptic plasticity More info
Prof. Robert S. Zucker


  • What is short-term synaptic plasticity?
  • Use of quantal analysis to show that plasticity arises presynaptically
  • Synaptic depression and the "Depletion Model"
  • Relationship of depletion model parameters to binomial statistical parameters
  • Refinements to the depletion hypothesis
  • Origin of slow phases of depression
  • Role of multiple vesicle pools
  • Role of vesicle endocytosis
  • Role for calcium in recovery
  • Why depression is sometimes absent
  • Other forms of depression
  • Phases of synaptic enhancement: facilitation, augmentation, and potentiation
  • Presynaptic electrical events in synaptic enhancement
  • Calcium and the nonlinear summation single site hypothesis
  • Kinetic components of calcium removal
  • Multiple sites of calcium action
  • Problems with identifying molecular mediators
  • Candidate molecular mediators
  • A comprehensive model of presynaptic plasticity
  • Other forms of synaptic enhancement
  • Computational roles of short-term synaptic plasticity
  • Physiological roles of short-term synaptic plasticity
Play 'Stem cells derived from amniotic fluid and placenta'


  • Introduction to the amniotic fluid and placenta
  • Collecting stem cells from the amniotic fluid or placenta
  • Cell markers in amniotic fluid or placenta derived stem cells
  • Amniotic fluid or placenta derived stem cells are able to form embryoid bodies
  • Uses of amniotic fluid or placenta derived stem cells: Immunomodulation
  • Uses of amniotic fluid or placenta derived stem cells: Regenerative medicine
  • Amniotic fluid or placenta derived stem cells can be differentiated into a variety of cell types
  • Amniotic fluid stems cells in the kidney
  • Necrotizing enterocolitis; a model and treatment with amniotic fluid stems cells
  • Clinical uses of amniotic fluid or placenta derived stem cells
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Play 'The genetic basis of kidney cancer'
The genetic basis of kidney cancer More info
Dr. W. Marston Linehan


  • Renal Carcinoma
  • Stage I , Stage IV kidney cancer
  • Human Renal Epithelial Neoplasms
  • Loss of alleles in renal cell carcinoma
  • Mapping the Minimal 3p Loss Region in Clear Cell Renal Carcinoma
  • Studying Cancer Families to Identify Renal Carcinoma Genes
  • Identification of Kidney Cancer Genes
  • Inherited Forms of Renal Carcinoma
  • Clear Cell Renal Carcinoma: von Hippel Lindau (VHL)
  • VHL Gene
  • VHL Gene Localization Map
  • Germline VHL Mutations
  • Papillary Renal Carcinoma
  • Mouse Studies of VHL gene
  • VHL Gene Function
  • HIFα
  • Downstream effects of VHL mutation
  • Targeting VHL/HIF in Clear Cell RCC
  • TCGA Clear Cell Kidney Cancer
  • Intratumor Heterogeneity
  • Warburg effect in clear cell kidney cancer
  • Non-Clear Cell RCC
  • Locally Advanced Kidney Cancer
  • Hereditary Papillary Renal Carcinoma (HPRC)
  • Inherited Renal Carcinoma
  • Type 1 Papillary Renal Carcinoma
  • Penetrance of MET Mutation H1210R
  • MET Gene: Type 1 Papillary RCC
  • Location of the HPRC Gene
  • HPRC: Activating Mutations in the Tyrosine Kinase Domain of MET
  • Location of MET Mutations in the HPRC Patients
  • Targeting MET RCC Gene Pathway
  • Potential Small Molecule Target: MET Tyrosine Kinase Inhibition
  • Foretinib: Dual VEGFR and MET Inhibitor
  • MiT Kidney Cancer TFE3, TFEB, MITF
  • UOK124, Papillary Kidney Cancer
  • UOK124, UOK120, UOK 146 & TFE3 Kidney Cancer
  • Inherited Renal Carcinoma Birt-Hogg-Dubé (BHD)
  • Birt Hogg Dubé Cutaneous Manifestations
  • Kidney Tumors in BHD
  • BHD Renal Tumor Pathology
  • BHD Lung Cysts
  • Identification of the BHD Gene
  • Cutaneous Fibrofolliculomas
  • BHD Gene: Chromophobe RCC
  • BHD Gene Locus: Chromosome 17
  • BHD Protein Sequence
  • FLCN Mutation Spectrum
  • Therapeutic Approach: What Kind of Gene is FLCN?
  • BHD Gene Analysis in BHD-Associated RCC
  • Somatic mutations in renal tumors from BHD patients
  • UOK 257, BHD -/- RCC cell line Study
  • How Does the FLCN Gene Function?
  • Folliculin-FNIP1/2-AMPK Interactions
  • mTORC1/mTORC2 Activation: FLCN-Deficient Kidney Cancer
  • BHD Deletion Specifically in the Kidney
  • BHDf/d/KSPCre Mouse Kidney Study
  • Hereditary Leiomyomatosis Renal Cell Carcinoma (HLRCC)
  • HLRCC: Cutaneous Manifestations, Uterine Leiomyomas
  • HLRCC: Papillary Kidney Cancer Type 2
  • Orangophilic Nucleoli + Perinucleolar Halos
  • Fumarate Hydratase Gene: HLRCC
  • UOK-262 Study
  • Loss of a Krebs Cycle Enzyme Can Lead to Kidney Cancer
  • Impaired citric acid cycle and “Warburg effect”
  • HLRCC-Renal Cancer: Glucose-Dependent
  • PET Scan
  • HLRCC novel treatment approaches
  • Kidney Cancer: a Metabolic Disease


Play 'G-Protein coupled receptors in drug discovery'
G-Protein coupled receptors in drug discovery More info
Dr. Mark Wigglesworth


  • The G-protein coupled receptor superfamily
  • GPCRs as drug targets
  • Approved GPCR drugs
  • why the reduction in GPCR drugs
  • new screening technologies and new drug targets
Play 'Barrier mechanisms in the developing brain: protection or vulnerability?'
Barrier mechanisms in the developing brain: protection or vulnerability? More info
Prof. Norman Saunders


  • The brain develops within a well-defined internal environment
  • The properties of this internal environment are determined by transporters in the cellular interfaces between the blood, brain and cerebrospinal fluid
  • The transporters are effective because the intercellular spaces between the cells in the interfaces are sealed by tight junctions
  • The transporters are both influx and efflux and many are active very early in brain development
  • Although brain barrier mechanisms are present very early in development they are vulnerable to pathological conditions e.g. inflammation, which may result in barrier dysfunction and damage to the fragile developing brain
  • These mechanisms thus provide protection and a stable internal environment, but some may render the developing brain more vulnerable e. g. inward transport of toxins such as mercury via a normal amino acid transporter
Play 'Plant cell wall: structure and biosynthesis'
Plant cell wall: structure and biosynthesis More info
Prof. Debra Mohnen
Dr. Melani A. Atmodjo


  • Overview of plant cell wall functions
  • Primary and secondary walls
  • Types of polymers in plant cell walls
  • Organization of plant cell walls / plant cell wall models
  • Cell wall proteins
  • Structure and synthesis of lignin
  • Structure and synthesis of cellulose
  • Structure and synthesis of hemicelluloses
  • Structure and synthesis of pectic polysaccharides


"This is truly the future now. The lectures are so concise and informative, and an excellent teaching tool."
Prof. Virginia Sanders
The Ohio State University, USA

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