Henry Stewart Talks

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Talks (188) Series (32)
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TALKS PUBLISHED/UPDATED IN THE LAST TWELVE MONTHS
September 2014
1. Hox gene regulation in vertebrate hindbrain development (59 mins)
Play '1. Hox gene regulation in vertebrate hindbrain development'
SpeakersProf. Robb Krumlauf  –  Stowers Institute for Medical Research, USA
Series Epigenetics, Chromatin, Transcription and Cancer
Relevant
    extract
Origins and diversity of the basic animal body plan - Ernst Haeckel: Anthropogenie, “Tree of life” - Common mechanisms for vertebrate body plan - How does diversity follow from similarity? - Hox h... more More info
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2. Gene therapy for the muscular dystrophies (66 mins)
Play '2. Gene therapy for the muscular dystrophies'
SpeakersProf. Jeff Chamberlain  –  University of Washington, USA
Series Gene Transfer and Gene Therapy
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    extract
Introduction to the muscular dystrophies - Duchenne muscular dystrophy (DMD) - Dystrophin, the gene product of the DMD locus - The molecular basis of DMD - Strategies for the development of DMD t... more More info
3. Lentiviral vectors: design, biological properties, milestones and current major applications, hazards - Part 1 of 2 (58 mins)
Play '3. Lentiviral vectors: design, biological properties, milestones and current major applications, hazards - Part 1 of 2'
SpeakersProf. Luigi Naldini  –  Telethon Institute for Gene Therapy, Italy
Series Gene Transfer and Gene Therapy
Relevant
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Properties of retroviral vectors: Genetic stability in target cells, Transgene expression, Fidelity of replication, Target cell spectrum, Transdution efficiency, Toxicity, RCR or WT virus contamina... more More info
UG 
4. Lentiviral vectors: design, biological properties, milestones and current major applications, hazards - Part 2 of 2 (38 mins)
Play '4. Lentiviral vectors: design, biological properties, milestones and current major applications, hazards - Part 2 of 2'
SpeakersProf. Luigi Naldini  –  Telethon Institute for Gene Therapy, Italy
Series Gene Transfer and Gene Therapy
Relevant
    extract
Lentiviral vectors: applications, gene transfer efficiency and transgene expression - Therapeutic potential of HSC gene therapy - Vector integration site analysis - Lentiviral-mediated HSC gene tra... more More info
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5. Tracking vector insertion sites to explore the biology of transduced cells in vivo (35 mins)
Play '5. Tracking vector insertion sites to explore the biology of transduced cells in vivo'
SpeakersProf. Dr. Christof Von Kalle  –  National Center for Tumor Diseases and German Cancer Research Center, Germany
Series Gene Transfer and Gene Therapy
Relevant
    extract
Clonal marking by integrating vectors - Integration site analysis by LAM-PCR - Analysis of gene therapy clinical trials for X-SCID, X-CGD, ADA-SCID & Cancer - Avoiding oncogenesis in gene therapy -... more More info
6. Chromatin genes and disease (34 mins)
Play '6. Chromatin genes and disease'
SpeakersProf. Richard Gibbons  –  University of Oxford, UK
Series Molecular Genetics of Human Disease
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    extract
Chromatin genes and disease - Epigenetics: the phenotype reflects the pattern of gene expression - The role of chromatin in epigenetic regulation - Epigenetic factors and their role in gene express... more More info
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7. PTEN Hamartoma-Tumour Syndrome: a model for the practice of clinical cancer genetics (21 mins)
Play '7. PTEN Hamartoma-Tumour Syndrome: a model for the practice of clinical cancer genetics'
SpeakersProf. Charis Eng  –  Cleveland Clinic, USA
Series Molecular Genetics of Human Disease
Relevant
    extract
PTEN Hamaratoma Tumour Syndrome: A Model for the Practice of Clinical Cancer Genetics Clinical cancer genetics - Evaluating and managing families with inherited cancer syndromes - Recognition of cl... more More info
8. Molecular genetics of pulmonary arterial hypertension (21 mins)
Play '8. Molecular genetics of pulmonary arterial hypertension'
SpeakersProf. Richard C. Trembath  –  Queen Mary University of London , UK
Series Molecular Genetics of Human Disease
Relevant
    extract
Histopathology of PAH - Familial PAH: classical linkage - Variable age of onset and penetrance - Pathogenesis of HHT & PAH - Key genes in the pathogenesis of PAH - The BMPR2 mutation (classificatio... more More info
9. Hematopoietic stem cell gene therapy for the treatment of metachromatic leukodystrophy (37 mins)
Play '9. Hematopoietic stem cell gene therapy for the treatment of metachromatic leukodystrophy'
SpeakersDr. Alessandra Biffi  –  Telethon Institute for Gene Therapy, Italy
Series Gene Transfer and Gene Therapy
Relevant
    extract
Metachromatic Leukodystrophy (MLD) - Hematopoietic stem cell therapy (HCT) for lysosomal storage disorders (LSDs) - Improving HCT efficacy - The role of brain pre-conditioning - Mechanisms of mic... more More info
10. Congenital sydromes of pain and painlessness (57 mins)
Play '10. Congenital sydromes of pain and painlessness'
SpeakersProf. Geoff Woods  –  University of Cambridge, UK
Series Molecular Genetics of Human Disease
Relevant
    extract
What is pain? - How much pain is someone suffering? - What is the use of pain? - Pain pathways - Types of pain (Nociceptive, Inflammatory, Neuropathic, mixed) - Primary erythromelalgia - Mutations... more More info
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