Henry Stewart Talks

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Talks (159) Series (29)
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TALKS PUBLISHED/UPDATED IN THE LAST TWELVE MONTHS
April 2014
1. Presynaptic plasticity (54 mins)
Play '1. Presynaptic plasticity'
SpeakersProf. Robert S. Zucker  –  University of California, USA
Series Synapses, Neurotransmitters and Receptor Channels
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What is short-term synaptic plasticity? - Use of quantal analysis to show that plasticity arises presynaptically - Synaptic depression and the "Depletion Model" - Relationship of depletion model pa... more More info
2. NMDA Receptors: neuroprotective or excitotoxic? (44 mins)
Play '2. NMDA Receptors: neuroprotective or excitotoxic?'
SpeakersProf. Giles E. Hardingham  –  University of Edinburgh, UK
Series Synapses, Neurotransmitters and Receptor Channels
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Excitotoxicity - Historical background, implication of NMDA receptors and role in acute and chronic disorders - Pro-survival signaling to gene expression from the NMDA receptor - Mechanisms of exci... more More info
3. Structure of the GABA/A receptor (44 mins)
Play '3. Structure of the GABA/A receptor'
SpeakersProf. Trevor Smart  –  University College, London, UK
Series Synapses, Neurotransmitters and Receptor Channels
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The structure & molecular properties the GABA/A receptor - GABA/A receptor subunit families and subtype abundance & diversity - GABA receptor activation - GABA/A receptor role in physiology & disea... more More info
4. Purinoceptors and fast purinergic transmission at neuromuscular junctions and synapses (48 mins)
Play '4. Purinoceptors and fast purinergic transmission at neuromuscular junctions and synapses'
SpeakersProf. Geoff Burnstock  –  University College London, UK
Series Synapses, Neurotransmitters and Receptor Channels
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Purinergic transmission and the role of ATP as a neurotransmitter - Neuromuscular junctions and neuromodulation - Synaptic transmission in peripheral and central nervous systems - NANC excitatory a... more More info
5. Visualization of transcription factor interactions in living cells (48 mins)
Play '5. Visualization of transcription factor interactions in living cells'
SpeakersProf. Tom Kerppola  –  University of Michigan, USA
Series Eukaryotic Gene Regulation
Epigenetics, Chromatin, Transcription and Cancer
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Transcription regulatory proteins - Combinatorial control of gene expression - Visualization of transcription factor interactions and modifications in living cells - New methods development - Bimol... more More info
6. DNA methylation (51 mins)
Play '6. DNA methylation'
SpeakersProf. Steve Jacobsen  –  University of California, Los Angeles, USA
Series Eukaryotic Gene Regulation
Epigenetics, Chromatin, Transcription and Cancer
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    extract
Roles of DNA methylation - Evolution of eukaryotic DNA methyltransferases - Mechanism of action of DNA methyltransferases - Specific loci targeting - Histone modification - Small interfering RNA more More info
7. Development, testing and introduction of new diagnostic tools for tuberculosis (35 mins)
Play '7. Development, testing and introduction of new diagnostic tools for tuberculosis'
SpeakersDr. Mark Perkins  –  FIND, Geneva, Switzerland
Series Tuberculosis
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Tuberculosis: current diagnostics tests - microscopy diagnosis in endemic countries - the important distinction between smear negative and smear positive patients -introduction of DOTS - limitation... more More info
8. Enhancer malfunction in cancer (41 mins)
Play '8. Enhancer malfunction in cancer'
SpeakersDr. Ali Shilatifard  –  Stowers Institute, USA
Series Epigenetics, Chromatin, Transcription and Cancer
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MLL genes and their pathogenic translocations - Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis - Proteins and protein complexes that regulate chromatin modifications, t... more More info
9. Infection in the cystic fibrosis lung (52 mins)
Play '9. Infection in the cystic fibrosis lung'
SpeakersDr. Stuart Elborn  –  Queen’s University Belfast, UK
Series Respiratory Infection
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Cystic fibrosis (CF) pathophysiology of infection and inflammation - Identification of bacteria and other macro-organisms using sequencing techniques in airways of people with CF - Treatment & prev... more More info
10. Inhibiting protein-protein interactions - part 1 of 2 (41 mins)
Play '10. Inhibiting protein-protein interactions - part 1 of 2'
SpeakersDr. Adrian Whitty  –  Boston University, USA
Series Small Molecule Drug Discovery
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The druggable proteome - Objectives - Five propositions about the druggability of PPI targets - Classification of PPI targets - Why are small molecule inhibitors of PPI hard to obtain? - PPI topolo... more More info
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