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Introduction to free radicals and oxidative stress: "the oxygen paradox"

Prof. Kelvin Davies, University of Southern California, USA
Duration: 56:53 mins

Series: Free Radicals and the Oxygen Paradox: Oxidative Stress in Biology, Aging and Disease

Talk Summary

The oxygen paradox – Oxygen origin – Free radicals, oxidants and oxidative stress – Sources of free radicals – Environmental toxins – Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation – Medical and dental sources of free radicals: x-rays, g-rays, drugs – DNA damage and oxygen radical toxicity – Antioxidant compounds and enzymes – The dismutation of superoxide – Mechanisms of antioxidant enzymes – Antioxidant defense and repair systems – Removal of oxidized DNA bases and DNA repair – Lipolysis and the repair of oxidized lipids and lipid membranes – Selective proteolytic degradation of oxidized proteins – The LON protease – Adaptation to oxidative stress – Long-term effects of free radicals and oxidative stress: aging and disease

Biography

Prof. Kelvin Davies, University of Southern California, USA
Kelvin Davies is the James E. Birren Chair of Gerontology at the University of Southern California. He was educated at London University, the University of Wisconsin and the University of California at Berkeley. He was previously a facutly member at Harvard University and Albany Medical College. Professor Davies is the (founding) Editor-in-Chief of Free Radical Biology & Medicine and President of the International Society for Free Radical Research. His research centers on the role of free radicals and oxidative stress in biology. In particular he is interested in genes that repair oxidatively damaged proteins, lipids, RNA and DNA.

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